SSLHandshakeException exception is noticed with RPE 2.1.2 while connecting to DNG, RTC, RQM in few environments. This is happening due to the mismatch in ciphers.
One way to fix it is to add cipher supported in RPE into CLM. See http://www-01.ibm.com/support/docview.wss?uid=swg22007595 for details.
Another way is use swap JRE directory from RPE 2.1.1 to RPE 2.1.2. The jre direction is found in RPE_INSTALLATION_PATH directory.